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Research data supporting Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in Schistosoma haematobium and Schistosoma mansoni infection


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Type

Dataset

Change log

Authors

Oettle, Rebecca C 
Dickinson, Harriet A 
Fitzsimmons, Colin M 
Sacko, Moussa 
Tukahebwa, Edridah M 

Description

Individual level S. mansoni infection data obtained from individuals residing in a fishing village in the Lake Victoria region, Uganda, Musoli. Data include human host age; baseline S. mansoni egg counts, 9-week post-treatment Kato Katz S. mansoni egg counts (eggs/gram feces); 2-year post-treatment Kato Katz S. mansoni egg counts (epg), and post-treatment IgE-TAL titers (ng/ul). Detailed descriptions of the study cohorts, data collection and analysis can be found in: Fitzsimmons et al. 2012 DOI:10.1128/IAI.00641-12

Individual level S. haematobium infection data from three villages in the Segou Region, Mali. Data include human host age, sex and residence in high or moderate transmission intensity villages; pre-treatment baseline CAA measurement; 9-week post-treatment urine filtration S. haematobium egg counts (eggs/10 ml urine); 2-year post-treatment infection status (presence/absence of S. haematobium eggs by urine filtration); post-treatment seroprevalence of measurable IgE responses to specified members of the Tegument Allergen Like protein family (compared to non-endemic control response, data also available); pre-treatment IgE and IgG4 seroprevalence to specific ShTAL proteins; pre- and post-treatment IgE-TAL titers (ng/ul). Detailed descriptions of the study cohorts, data collection and analysis can be found in: Wilson et al. 2014 DOI: 10.1093/infdis/jiu374

Version

Software / Usage instructions

Data analysis performed in R version 3.4 R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2015. Available from: https://www.r-project.org/.

Keywords

Human, IgE, Immunity, Schistosoma

Publisher

Sponsorship
Medical Research Council (MR/M019780/1)
This study was funded by Medical Research Council, UK (grant MR/M019780/1). RCO was funded by the Medical Research Council, UK Doctoral Training Partnership (grant MR/K50127X/1). The original field studies were supported by the Commission of the European Community’s Science and Technology for Development Programme (contract 517733 [MUSTSchistUKEMA]).
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