Vaccine hesitancy, defined as the delayed acceptance or refusal of available vaccination, is a threat to public health. It increases the spread of communicable disease through the reduction of vaccine uptake. Therefore, it is imperative to develop public health strategies which effectively decrease vaccine hesitancy. In order to reduce hesitancy and increase uptake, educational interventions are commonly used to educate the vaccine-hesitant population about vaccine safety. Many current educational interventions are generalised educational interventions, meaning they provide individuals with generic vaccine information that may not address their specific concerns. In contrast, targeted educational interventions allow individuals to indicate their reasons for remaining hesitant about vaccination and have them directly addressed. This paper argues that targeted educational intervention should be further emphasised in public health strategies for reducing COVID-19 and influenza vaccine hesitancy. Reasons for COVID-19 and influenza vaccine hesitancy are extremely diverse and dependent on the individual and their healthcare history. Targeted interventions are more effective in the addressal of these diverse and specific concerns. This paper reviews external literature regarding the efficacy of targeted educational intervention in reducing both influenza and COVID-19 vaccine hesitancy. The results indicate that generalised educational interventions alone are often insufficient to reduce vaccine hesitancy, while targeted educational interventions are effective at both reducing vaccine hesitancy and increasing vaccine uptake. Thus, the results of this systematic literature review support the notion that vaccination campaigns should emphasise targeted interventions as a key component of their strategy.