Research data in support of "A synthetic signalling network imitating the action of immune cells in response to bacterial metabolism"
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This repository contains raw data in support of the publication 10.1002/adma.202301562. Please refer to the published paper, available open access, for full information and context.
Figure 2 data
- Panel b: Confocal image of core-shell particle
- Panel d: Absorbance data to probe pH responsiveness of the DNA constructs
- Panel c: CD data to probe pH responsiveness of the DNA constructs
- Panel g: Representative epifluorescence and bright field images and bright field videos to demonstrate pH-induced particle aggregation
Figure 3 data
- Panel b: pH and OD data vs E. coli growth time in various glucose concentrations
- Panels d, e; Representative epifluorescence images and bright field videos to demonstrate E. coli induced particle aggregation and bacteria trapping
- Panel f: OD data vs E. coli growth time
Figure 4 data
- Panel b: OD data vs E. coli growth time showing effect of netosis-like synthetic pathway
- Panel e: Representative bright field and epifluorescence images showing effect of netosis-like synthetic pathway
Supplementary Figure 1: Agarose gel demonstrating DNA construct assembly
Supplementary Figure 2: DLS data showing pH responsiveness of DNA nanostructures
Supplementary Figure 3: UV melting curve data for DNA constructs
Supplementary Figure 4: DLS data underpinning pH response curve
Supplementary Figure 5: Representative data provided in Figure 2, Panel g folder
Supplementary Figure 6: Representative microscopy videos used to generate hydrodynamic radius data with DDM
Supplementary Figure 7: OD data vs E. coli growth time at various glucose concentrations
Supplementary Figure 8: FITC dextran fluorescence intensity data (used to determine pH) vs E. coli growth time at various glucose concentrations
Supplementary Figure 9: Calibration data (FITC dextran fluorescence vs pH) used in Figure 3f and Supplementary Figures 8 and 12
Supplementary Figure 10: FITC dextran fluorescence intensity data (used to determine pH in Figure 3f) vs E. coli growth time at various glucose concentrations
Supplementary Figure 11: Representative data provided in Figure 3, Panel d, e folder
Supplementary Figure 12: FITC dextran fluorescence intensity data (used to determine pH) vs E. coli growth time Supplementary Figure 13: Calibration data (Fluorescein dT fluorescence vs pH) for fluorescent pH probe linked to DNA particles
Supplementary Figure 14: Fluorescent data for pH-induced de-quenching on DNA particles
Supplementary Figure 15: OD vs E. coli growth time at various antibiotic concentrations
Supplementary Figure 16: Representative data provided in Figure 4, Panel c, folder
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Royal Society (UF160152)