| Title: | A new deep branch of eurasian mtDNA macrohaplogroup M reveals additional complexity regarding the settlement of Madagascar |
| Authors: | Ricaut, Francois-X Razafindrazaka, Harilanto Cox, Murray P Dugoujon, Jean-M Guitard, Evelyne Sambo, Clement Mormina, Maru Mirazon-Lahr, Marta Ludes, Bertrand Crubezy, Eric |
| Issue Date: | 14-Dec-2009 |
| Citation: | BMC Genomics 2009, 10:605 |
| Abstract: | Abstract Background Current models propose that mitochondrial DNA macrohaplogroups M and N evolved from haplogroup L3 soon after modern humans left Africa. Increasingly, however, analysis of isolated populations is filling in the details of, and in some cases challenging, aspects of this general model. Results Here, we present the first comprehensive study of three such isolated populations from Madagascar: the Mikea hunter-gatherers, the neighbouring Vezo fishermen, and the Merina central highlanders (n = 266). Complete mitochondrial DNA genome sequences reveal several unresolved lineages, and a new, deep branch of the out-of-Africa founder clade M has been identified. This new haplogroup, M23, has a limited global distribution, and is restricted to Madagascar and a limited range of African and Southwest Asian groups. Conclusions The geographic distribution, phylogenetic placement and molecular age of M23 suggest that the colonization of Madagascar was more complex than previously thought. |
| Description: | RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are. |
| URI: | http://www.dspace.cam.ac.uk/handle/1810/237885 http://dx.doi.org/10.1186/1471-2164-10-605 |
| Appears in Collections: | Scholarly works - Biological Anthropology |
Files in This Item:
|
| Additional resources for this item |
|---|
| search for alternative versions in eresources@cambridge |
| retrieve citation metadata in EndNote format |
This item has been accessed 304 times.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.