Repository logo
 

Unambiguous detection of cardiac Pi using long TM 31P STEAM

Accepted version
Peer-reviewed

Type

Conference Object

Change log

Authors

Schmid, Albrecht Ingo 
Valkovic, Ladislav 
Tunnicliffe, Elizabeth M 
Rodgers, CT 

Abstract

Synopsis Inorganic Phosphate is a resonance that holds important information on the metabolic state of tissues. From its resonance frequency, intracellular pH can be derived. The ratio of P to PCr or ATP are also important markers. Unlike in other tissues, myocardial P is frequently hidden underneath blood DPG signals. Using STEAM's T delay to be one cardiac cycle, blood-pool originating signals are gone and the Pi resonance is clearly visible. In 3 subjects, P signal was detected and quantified. The signal was around 4.89±0.02ppm, corresponding to a pH of 7.08±0.02. This is a breakthrough for the investigation of cardiac metabolism.

Description

Keywords

Journal Title

Proceedings of the International Society for Magnetic Resonance in Medicine

Conference Name

ISMRM 2018

Journal ISSN

Volume Title

Publisher

International Society for Magnetic Resonance in Medicine
Sponsorship
Wellcome Trust (Unknown)
This work was supported by the Austrian Science Fund (FWF) project J 4043 as well as by the Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (098436/Z/12/Z).