Unambiguous detection of cardiac Pi using long TM 31P STEAM
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Peer-reviewed
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Authors
Schmid, Albrecht Ingo
Valkovic, Ladislav
Tunnicliffe, Elizabeth M
Rodgers, CT
Abstract
Synopsis Inorganic Phosphate is a resonance that holds important information on the metabolic state of tissues. From its resonance frequency, intracellular pH can be derived. The ratio of P to PCr or ATP are also important markers. Unlike in other tissues, myocardial P is frequently hidden underneath blood DPG signals. Using STEAM's T delay to be one cardiac cycle, blood-pool originating signals are gone and the Pi resonance is clearly visible. In 3 subjects, P signal was detected and quantified. The signal was around 4.89±0.02ppm, corresponding to a pH of 7.08±0.02. This is a breakthrough for the investigation of cardiac metabolism.
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Journal Title
Proceedings of the International Society for Magnetic Resonance in Medicine
Conference Name
ISMRM 2018
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International Society for Magnetic Resonance in Medicine
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Wellcome Trust (Unknown)
This work was supported by the Austrian Science Fund (FWF) project J 4043 as well as by the Sir Henry Dale Fellowship from the Wellcome Trust and the
Royal Society (098436/Z/12/Z).