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Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar.


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Authors

Suberu, John 
Gromski, Piotr S 
Nordon, Alison 

Abstract

An improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) protocol for rapid analysis of co-metabolites of A. annua in raw extracts was developed and extensively characterized. The new method was used to analyse metabolic profiles of 13 varieties of A. annua from an in-field growth programme in Madagascar. Several multivariate data analysis techniques consistently show the association of artemisinin with dihydroartemisinic acid. These data support the hypothesis of dihydroartemisinic acid being the late stage precursor to artemisinin in its biosynthetic pathway.

Description

Keywords

Artemisia annua, Metabolic profiling, Multivariate data analysis, Artemisia annua, Madagascar, Metabolomics, Multivariate Analysis, Plant Extracts, Plant Leaves, Statistics as Topic

Journal Title

J Pharm Biomed Anal

Conference Name

Journal ISSN

0731-7085
1873-264X

Volume Title

117

Publisher

Elsevier BV
Sponsorship
The research leading to these results has received funding from Engineering and Physical Sciences Research Council project “Closed Loop Optimization for Sustainable Chemical Manufacture” [EP/L003309/1].