Identification of the first surrogate agonists for the G protein-coupled receptor GPR132
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Authors
Shehata, MA
Belcik Christensen, H
Isberg, V
Sejer Pedersen, D
Abstract
We report the first pharmacological tool agonist for in vitro characterization of the orphan receptor GPR132, preliminary structure–activity relationships based on 32 analogs and a suggested binding mode from docking.
Description
Keywords
3404 Medicinal and Biomolecular Chemistry, 34 Chemical Sciences, Cardiovascular, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions
Journal Title
RSC Advances
Conference Name
Journal ISSN
2046-2069
2046-2069
2046-2069
Volume Title
5
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
M.A.S. was supported by a research scholarship from the
Drug Research Academy and Novo Nordisk A/S. D.E.G.
and H.B.-O. gratefully acknowledge financial support by
the Carlsberg Foundation. D.E.G. and D.S.P. gratefully
acknowledges financial support by the Lundbeck
Foundation. Nils Nyberg is acknowledged for help with
NMR spectroscopy. NMR equipment used in this work
was purchased via a grant from The Lundbeck
Foundation (R77-A6742).