Synthesis of fluorosugar reagents for the construction of well-defined fluoroglycoproteins.
Change log
Authors
Salvadó, Míriam
Amgarten, Beatrice
Castillón, Sergio
Bernardes, Gonçalo JL
Boutureira, Omar
Abstract
2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-β-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such β-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.
Description
Keywords
Glycoproteins, Glycosides, Glycosylation, Hydrocarbons, Fluorinated, Indicators and Reagents, Molecular Structure
Journal Title
Org Lett
Conference Name
Journal ISSN
1523-7060
1523-7052
1523-7052
Volume Title
17
Publisher
American Chemical Society (ACS)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/M003647/1)
We thank the European Commission (Marie Curie CIG, O.B. and G.J.L.B.), MICINN, Spain (Juan de la Cierva Fellowship, O.B.), MINECO, Spain (CTQ2011-22872BQU) and Generalitat de Catalunya (M.S.) for generous financial support. We also thank Mr. Adrià Cardona-Benages (URV) for technical assis-tance. G.J.L.B. thanks the Royal Society (University Research Fellowship), Fundação para a Ciência a Tecnologia, Portugal (FCT Investigator), and the EPSRC for funding.