Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells
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Authors
Thaker, Youg Raj
Rudd, Christopher E
Abstract
The transcription factor nuclear factor-kB (NF-kB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-kB activation in T-cells. Progress in understanding NF-kB activation in T-cells has occurred over the years with the identification of individual adapters such as ADAP and GRB-2 and enzymes such as PKC-θ that regulate NF-kB. However, little is known whether the engagement of distinct modules by the TCR and CD28 account for the cooperative effects of the two receptors in activating NF-kB. In this review, we discuss recent advances in our understanding of NF-kB regulation by TCR and CD28.
Description
Keywords
Adaptors, ADAP, VAV-1, GRB-2, NF-kB
Journal Title
Inflammation and Cell Signaling
Conference Name
Journal ISSN
2330-779X
2330-7803
2330-7803
Volume Title
2
Publisher
Smart Science and Technology, LLC
Publisher DOI
Sponsorship
This work was supported by Wellcome Trust Program Grant (PG) PKAG/504 to Principal Research Fellow (PRF) C.E. Rudd.