Repository logo
 

Consensus on the management of intracranial germ-cell tumours.


Change log

Authors

Murray, Matthew J 
Bartels, Ute 
Nishikawa, Ryo 
Fangusaro, Jason 
Matsutani, Masao 

Abstract

The management of intracranial germ-cell tumours is complex because of varied clinical presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary input. Participants of the 2013 Third International CNS Germ Cell Tumour Symposium (Cambridge, UK) agreed to undertake a multidisciplinary Delphi process to identify consensus in the clinical management of intracranial germ-cell tumours. 77 delegates from the symposium were selected as suitable experts in the field and were invited to participate in the Delphi survey, of which 64 (83%) responded to the invitation. Invited participants represented multiple disciplines from Asia, Australasia, Europe, and the Americas. 38 consensus statements encompassing aspects of intracranial germ-cell tumour work-up, staging, treatment, and follow-up were prepared. To achieve consensus, statements required at least 70% agreement from at least 60% of respondents. Overall, 34 (89%) of 38 statements met consensus criteria. This international Delphi approach has defined key areas of consensus that will help guide and streamline clinical management of patients with intracranial germ-cell tumours. Additionally, the Delphi approach identified areas of different understanding and clinical practice internationally in the management of these tumours, areas which should be the focus of future collaborative studies. Such efforts should translate into improved patient outcomes.

Description

Keywords

Asia, Australasia, Brain Neoplasms, Delphi Technique, Disease Management, Europe, Humans, Neoplasms, Germ Cell and Embryonal

Journal Title

Lancet Oncol

Conference Name

Journal ISSN

1470-2045
1474-5488

Volume Title

16

Publisher

Elsevier BV