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Potential of human induced pluripotent stem cells in studies of liver disease.


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Authors

Sampaziotis, Fotios  ORCID logo  https://orcid.org/0000-0003-0812-7586
Segeritz, Charis-Patricia 

Abstract

Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long-term viability of isolated and diseased liver cells. The emergence of human induced pluripotent stem cells and differentiation protocols to generate hepatocyte-like cells has opened the possibility of addressing these issues. Here, we discuss the recent progress and potential in the production of various cell types constituting the liver and their applications to model liver diseases and test drug toxicity in vitro.

Description

Keywords

Chemical and Drug Induced Liver Injury, Hepatocytes, Humans, Induced Pluripotent Stem Cells, Liver Diseases, Proteostasis Deficiencies

Journal Title

Hepatology

Conference Name

Journal ISSN

0270-9139
1527-3350

Volume Title

62

Publisher

John Wiley and Sons Inc.
Sponsorship
Medical Research Council (MR/L016761/1)
Medical Research Council (G1000847)
Medical Research Council (G0800784)
FS is supported by an Addenbrooke’s Charitable Trust Clinical Research Training Fellowship, a joint Sparks-MRC Clinical Research Training Fellowship and the Cambridge Hospitals National Institute for Health Research Biomedical Research Center. CPS is supported by the Children’s Liver Disease Foundation. LV is supported by the ERC starting grant Relieve IMDs, the Cambridge Hospitals National Institute for Health Research Biomedical Research Center and the EuFp7 grants InnovaLIV and TissuGEN.