Nanopores formed by DNA origami: a review.
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Authors
Bell, Nicholas AW
Keyser, Ulrich F
Abstract
Nanopores have emerged over the past two decades to become an important technique in single molecule experimental physics and biomolecule sensing. Recently DNA nanotechnology, in particular DNA origami, has been used for the formation of nanopores in insulating materials. DNA origami is a very attractive technique for the formation of nanopores since it enables the construction of 3D shapes with precise control over geometry and surface functionality. DNA origami has been applied to nanopore research by forming hybrid architectures with solid state nanopores and by direct insertion into lipid bilayers. This review discusses recent experimental work in this area and provides an outlook for future avenues and challenges.
Description
Keywords
DNA origami, Nanopores, Nanotechnology, Self-assembly, Single molecule, DNA, Lipid Bilayers, Nanopores, Nanotechnology, Nucleic Acid Conformation
Journal Title
FEBS Lett
Conference Name
Journal ISSN
0014-5793
1873-3468
1873-3468
Volume Title
588
Publisher
Wiley
Publisher DOI
Sponsorship
N.A.W.B. acknowledges funding from the EPSRC NanoDTC program and an EPSRC doctoral prize award, U.F.K. acknowledges funding from an ERC starting Grant.