Repository logo
 

Delusions and prediction error: clarifying the roles of behavioural and brain responses.


Loading...
Thumbnail Image

Type

Article

Change log

Authors

Corlett, Philip Robert 
Fletcher, Paul Charles 

Abstract

Griffiths and colleagues provided a clear and thoughtful review of the prediction error model of delusion formation [Cognitive Neuropsychiatry, 2014 April 4 (Epub ahead of print)]. As well as reviewing the central ideas and concluding that the existing evidence base is broadly supportive of the model, they provide a detailed critique of some of the experiments that we have performed to study it. Though they conclude that the shortcomings that they identify in these experiments do not fundamentally challenge the prediction error model, we nevertheless respond to these criticisms. We begin by providing a more detailed outline of the model itself as there are certain important aspects of it that were not covered in their review. We then respond to their specific criticisms of the empirical evidence. We defend the neuroimaging contrasts that we used to explore this model of psychosis arguing that, while any single contrast entails some ambiguity, our assumptions have been justified by our extensive background work before and since.

Description

Keywords

cognitive neuroscience, delusions, functional neuroimaging, prediction error, Brain, Cognition, Delusions, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Models, Neurological, Models, Psychological, Psychotic Disorders, Thinking

Journal Title

Cogn Neuropsychiatry

Conference Name

Journal ISSN

1354-6805
1464-0619

Volume Title

20

Publisher

Routledge
Sponsorship
Medical Research Council (G0001354)
Wellcome Trust (095692/Z/11/Z)
PRC was supported by the Connecticut State Department of Mental Health and Addiction Services, an IMHRO/Janssen Rising Star Translational Research Award and CTSA [grant number UL1 TR000142] from the National Center for Research Resources (NCRR) and the National Center for Advancing Translational Science (NCATS), components of the National Institutes of Health (NIH) and NIH road map for Medical Research. PCF is funded by the Wellcome Trust and Bernard Wolfe Health Neuroscience Fund.