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Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.


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Type

Article

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Authors

Jalloh, Ibrahim 
Carpenter, Keri LH 
Carpenter, T Adrian 
Menon, David K 

Abstract

The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into the brain and its subsequent metabolism. We review the methods used to study cerebral glucose metabolism with a focus on those used in clinical TBI studies. Arterio-venous measurements provide a global measure of glucose uptake into the brain. Microdialysis allows the in vivo sampling of brain extracellular fluid and is well suited to the longitudinal assessment of metabolism after TBI in the clinical setting. A recent novel development is the use of microdialysis to deliver glucose and other energy substrates labelled with carbon-13, which allows the metabolism of glucose and other substrates to be tracked. Positron emission tomography and magnetic resonance spectroscopy allow regional differences in metabolism to be assessed. We summarise the data published from these techniques and review their potential uses in the clinical setting.

Description

Keywords

Animals, Autoradiography, Brain Injuries, Energy Metabolism, Extracellular Fluid, Glucose, Humans, Magnetic Resonance Imaging, Microdialysis, Positron-Emission Tomography

Journal Title

Metab Brain Dis

Conference Name

Journal ISSN

0885-7490
1573-7365

Volume Title

30

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (G0802251)
Medical Research Council (G1002277)
TCC (None)
Medical Research Council (G0001354)
Medical Research Council (G1000183)