Inside and out: the activities of senescence in cancer.
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Authors
Abstract
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.
Description
Keywords
Animals, Cellular Senescence, Humans, Neoplasms, Precancerous Conditions, Signal Transduction, Tumor Microenvironment
Journal Title
Nat Rev Cancer
Conference Name
Journal ISSN
1474-175X
1474-1768
1474-1768
Volume Title
14
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Cancer Research UK (C14303/A17197)