The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system.
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Authors
Kwun, Min Jung
Hong, Hee-Jeon
Abstract
Glycopeptide antibiotics containing a hydrophobic substituent display the best activity against vancomycin-resistant enterococci, and they have been assumed to be poor inducers of the resistance system. Using a panel of 26 glycopeptide derivatives and the model resistance system in Streptomyces coelicolor, we confirmed this hypothesis at the level of transcription. Identification of the structural glycopeptide features associated with inducing the expression of resistance genes has important implications in the search for more effective antibiotic structures.
Description
Keywords
Anti-Bacterial Agents, Drug Resistance, Bacterial, Glycopeptides, Streptomyces coelicolor
Journal Title
Antimicrob Agents Chemother
Conference Name
Journal ISSN
0066-4804
1098-6596
1098-6596
Volume Title
Publisher
American Society for Microbiology
Publisher DOI
Sponsorship
Medical Research Council (G0700141)
This work was supported by the Royal Society (516002.K5877/ROG) and the Medical Research
Council (G0700141).