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The genetics of chronic obstructive pulmonary disease.


Type

Article

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Authors

Lomas, DA 
Silverman, EK 

Abstract

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.

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Keywords

Cloning, Molecular, Environment, Genetic Predisposition to Disease, Genome, Humans, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking

Journal Title

Respir Res

Conference Name

Journal ISSN

1465-9921
1465-9921

Volume Title

Publisher

Springer Science and Business Media LLC