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A metadata approach for clinical data management in translational genomics studies in breast cancer.


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Authors

Papatheodorou, Irene 
Crichton, Charles 
Morris, Lorna 
Maccallum, Peter 
METABRIC Group 

Abstract

BACKGROUND: In molecular profiling studies of cancer patients, experimental and clinical data are combined in order to understand the clinical heterogeneity of the disease: clinical information for each subject needs to be linked to tumour samples, macromolecules extracted, and experimental results. This may involve the integration of clinical data sets from several different sources: these data sets may employ different data definitions and some may be incomplete. METHODS: In this work we employ semantic web techniques developed within the CancerGrid project, in particular the use of metadata elements and logic-based inference to annotate heterogeneous clinical information, integrate and query it. RESULTS: We show how this integration can be achieved automatically, following the declaration of appropriate metadata elements for each clinical data set; we demonstrate the practicality of this approach through application to experimental results and clinical data from five hospitals in the UK and Canada, undertaken as part of the METABRIC project (Molecular Taxonomy of Breast Cancer International Consortium). CONCLUSION: We describe a metadata approach for managing similarities and differences in clinical datasets in a standardized way that uses Common Data Elements (CDEs). We apply and evaluate the approach by integrating the five different clinical datasets of METABRIC.

Description

Keywords

Breast Neoplasms, Computational Biology, Database Management Systems, Female, Genomics, Humans

Journal Title

BMC Med Genomics

Conference Name

Journal ISSN

1755-8794
1755-8794

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (G0300648)
Engineering and Physical Sciences Research Council (EP/F059345/1)