Sex chromosomes and genetic association studies.
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Authors
Clayton, David G
Abstract
Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems.
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Keywords
0604 Genetics, Genetics, Mental Health
Journal Title
Genome Med
Conference Name
Journal ISSN
1756-994X
1756-994X
1756-994X
Volume Title
Publisher
Springer Science and Business Media LLC